abstract |
PROBLEM TO BE SOLVED: To provide a compound useful for the treatment of a COX-2-dependent disease. SOLUTION: Formula (I) [Where, R is hydrogen, lower alkyl, (C 3 -C 6 ) cycloalkyl, hydroxy, halo, lower alkoxy, trifluoromethoxy, trifluoromethyl or cyano; and A is biaryl, optionally substituted β-naphthyl , Bicyclic heterocyclic aryl, (C 3 -C 6 ) cycloalkyl-monocyclic carbocyclic aryl, or (C 5 or C 6 ) cycloalkane fused-monocyclic carbocyclic aryl. ] Of the present invention, pharmaceutically acceptable salts thereof, and pharmaceutically acceptable esters thereof have been found to be useful in the treatment of COX-2 dependent diseases. [Selection figure] None |