| abstract |
A pharmaceutical composition with improved release comprising at least one form of tramadol selected from the group consisting of tramadol, its enantiomers, pharmaceutically acceptable salts thereof, and combinations thereof. A pharmaceutical composition with improved release comprising at least one form of tramadol selected from the group consisting of tramadol, its enantiomers, pharmaceutically acceptable salts thereof, and combinations thereof, comprising: The composition releases from about 0% to about 30% (by weight) of at least one form of tramadol after 2 hours, and from about 5% to about 22% (by weight) of at least one form of tramadol after 4 hours. Up to about 38% (by weight) of at least one form of tramadol is released after 6 hours, and over about 40% (by weight) of at least one form of tramadol after 8 hours. Pharmaceutical composition exhibiting in vitro dissolution properties as measured by release (measured at 75 rpm in 900 mL 0.1 N HCl at 37 ° C. by USP Basket method) To. [Selection figure] None |