abstract |
PROBLEM TO BE SOLVED: To provide a potent, stable and membrane penetrating small molecule non-peptide caspase inhibitor that causes effective inhibition of apoptosis in vivo. A compound represented by formula (I). Wherein X is CH or N; Y is halo, trifluorophenoxy or tetrafluorophenoxy; R2 is C1-6 straight or branched alkylalkyl; R3 is hydrogen, halo, OCF3, CN or CF3 R4 represents hydrogen, halo, OCF3, SR, CN, CF3, Ar, etc.) [Selection figure] None |