| abstract |
A novel compound having a membrane-bound prostaglandin E synthase-1 (mPGES-1) inhibitory activity and useful as a prophylactic and / or therapeutic agent for diseases involving mPGES-1 such as inflammatory diseases Provide. [Solution] A compound of the formula (I) or a salt thereof [wherein A 1 , A 2 and A 3 represent CX 3 , CX 4 and CX 5 , respectively, X 1 represents a halogen atom, cyano or the like, and X 2 , X 3 , X 4 , and X 5 each independently represent a hydrogen atom, a halogen atom, cyano, or the like, R 1 represents a hydroxyl group, a halogen atom, —Y 1 —Z 1, or the like, and Y 1 represents , A single bond, C 2-3 alkynylene, etc., Z 1 represents C 3-6 cycloalkyl, aryl, etc., R 2 and R 3 each independently represent a halogen atom, biphenyl, —Y 2 —Z 2 and the like, Y 2 represents a single bond, C 1-6 alkylene or the like, and Z 2 represents aryl, C 3-10 cycloalkyl or the like]. [Selection figure] None |