| abstract |
Disclosed are compositions and methods for the treatment and prevention of various sexually transmitted pathogens. For example, mucosal delivery of antigens using replication deficient gene delivery vehicles (particularly replication deficient alphavirus vectors and particles) is described. Also described are compositions comprising a mucosal adjuvant and one or more antigens derived from HIV. Also provided is the use of these gene delivery vehicles in inducing a mucosal, local and / or systemic immune response after a mucosal immunization regimen. The present invention includes a method of generating an immune response against an antigen. In certain embodiments, the method comprises administering to a target cell of a subject mucosal a replication-deficient gene delivery vehicle (or vector) comprising a polynucleotide encoding at least one antigen (or modified version thereof). Including, where the antigen (or modified form thereof) can stimulate an immune response in the subject. [Selection figure] None |