| abstract |
The present invention provides a dosage form that exhibits rapid dispersibility. The pharmaceutical composition comprises one or more active ingredients and a rapidly dispersible, non-compressible solid matrix comprising the one or more active ingredients. The matrix has a layered three-dimensional shape with a defined microscopic structure and includes a bulk material and a binder. The bulk material comprises a pharmaceutically acceptable compound in particulate form, and the binder adheres to the particles of the bulk material and binds the particles together, substantially pharmaceutically acceptable, substantially. When the composition is in contact with moisture, the three-dimensional shape is destroyed while releasing the one or more active ingredients to the subject within a period of less than 90 seconds when the composition comes into contact with moisture. The composition exhibits a porosity of 10% to 90% of the dosage form volume, a bulk density of 150 (mg / ml) to 1300 (mg / ml), a hardness of 1.0 kp to 20 kp, Having a fragility of less than 25%, the matrix has a layer configuration with the binder arrangement programmed into each layer. [Selection] Figure 1 |