| abstract |
Hyperlipidemia such as hypercholesterolemia, hypertriglyceridemia, hypoHDLemia and / or arteriosclerosis for mammals including humans, showing squalene synthetase inhibitory action and cholesterol synthesis inhibitory action Provision of a medicament useful for the prevention and / or treatment of a disease. The following general formula (1) (Wherein R 1 is a phenyl group which may have a substituent such as a C1-C6 alkoxy group, etc .; R 2a and R 2b are a hydrogen atom, a halogeno group, etc .; ring A is a benzene ring or aromatic heterocycle; R 3a and R 3b are a hydrogen atom, a halogeno group, etc .; X is CH 2 , O, S, etc .; R 4a is a hydrogen atom, etc .; R 4b is a carboxy group, a carboxy C1-C6 alkyl group, etc. The pharmaceutical containing the compound or its pharmacologically acceptable salt represented by this. [Selection figure] None |