| abstract |
Disclosed is a pharmaceutical composition for treating multidrug resistant cells. A pharmaceutical composition comprising an effective dose of a hyaluronan-interacting competitor to reduce cellular resistance to a drug. The hyaluronan interaction competitor is exemplified by a hyaluronan-binding protein, and more specifically, hyaluronidase that digests a hyaluronan polymer into a hyaluronan oligomer. This composition contains an “in vivo generated HA interaction competitor (CHI)”. For example, CHI is a ligand for the HA receptor or a decoy that can bind to HA. [Selection figure] None |