| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fec576c38e34882531ca37d6b922bf42 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B55-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-24 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-612
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-30 |
| filingDate |
2008-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76572bc2100ee5c047e61235865eb2ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd9c94cb75c25d75b0c5734b72b5af4c |
| publicationDate |
2010-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2010116331-A |
| titleOfInvention |
Process for producing α-substituted esters |
| abstract |
The present invention provides a practical method for producing α-substituted esters. An α-substituted ester can be produced by reacting a fluorosulfuric acid ester of an α-hydroxy ester with a Grignard reagent in the presence of a zinc catalyst. It has been newly found that a reaction that has been limited to an expensive trifluoromethanesulfonic acid ester as a raw material substrate can proceed well even with a fluorosulfuric acid ester suitable for large-scale production. In addition, by using the fluorosulfuric ester having a high optical purity, α-substituted esters having reversed stereochemistry can be obtained with a high optical purity. The present invention solves all the problems of the prior art and is a manufacturing method that can be implemented industrially. [Selection figure] None |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014183009-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014104221-A1 |
| priorityDate |
2008-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |