| abstract |
The present invention provides a method for searching for a substance that can be an active ingredient for preventing or treating the onset and progression of diabetic nephropathy. A method for selecting a patient with a high potential risk of developing diabetic nephropathy, and a reagent kit that can be effectively used in the method. In screening an active ingredient of an antidiabetic nephropathy agent, the following steps are performed: (1) A step of contacting a test substance with a cell capable of expressing an EHF gene, (2) a step of measuring the expression level of the EHF gene in the cell contacted with the test substance, and (3) a test substance in which the measurement amount is smaller than the expression level of the EHF gene in the control cell not contacted with the test substance Process to select. [Selection figure] None |