| abstract |
Kind Code: A1 The present invention relates to a mood state improving agent capable of effectively reducing stress, anxiety, aggression and aggressiveness, that is, a screening method for an anti-stress agent, and a transgenic in which a mental state is improved by the expression of VEGF. To provide a non-human mammal. A VEGF protein or a partial peptide of a VEGF protein which has substantially the same activity as the VEGF protein or a salt thereof, or a DNA encoding a VEGF protein or a partial peptide of a VEGF protein, the VEGF protein DNA encoding a peptide having substantially the same quality of activity, or DNA encoding a protein or peptide that hybridizes with these DNA under stringent conditions and has substantially the same quality of activity as VEGF protein An antistress agent comprising DNA as an active ingredient. [Selection figure] None |