| abstract |
The present invention provides a method for purification and concentration by biofiltration of biomolecules produced by synthesis of oligonucleotides, synthetic DNA, synthetic RNA, and the like. An ultrafiltration (UF) membrane having a nominal molecular weight cutoff (NMWCO) of about 0.5 KD to about 10 KD and having a positive or negative charge on the surface of the membrane 4 is used, and the charged surface is used. Then, the synthetic biomolecule is bounced back and held in the remaining liquid, or the synthetic biomolecule is purified and concentrated by preferentially sucking the synthetic biomolecule through membrane filtration. [Selection] Figure 2 |