| abstract |
[Problem] To provide a pharmaceutical composition that rapidly disintegrates when contained in the oral cavity and that exhibits sufficient hardness during normal production, transportation, and use, and is easy to handle, and more convenient and necessary. Provision of a method for producing the pharmaceutical composition capable of avoiding contact between the medicinal component and moisture depending on An aqueous solution of the component (C) is added to at least the following components (A) and (B) to perform wet granulation, and the resulting granulated product is subjected to compression molding treatment and further subjected to heat treatment. And (B) one or more sugar alcohols and / or sugars selected from erythritol, mannitol and lactose, and (C) xylitol, sorbitol and trehalose Containing one or more sugar alcohols and / or sugars selected from the group consisting of heat treatment temperature of 90 to 140 ° C., heat treatment time of 3 to 90 minutes, and compression molding pressure of 300 to 1500 kgf. In addition, the intraoral quick disintegrating tablet, wherein the heat treatment utilizes the sintering action of the component (C). [Selection figure] None |