| abstract |
The present invention provides its use in the treatment of diseases responsive to inhibition of protein kinase activity, especially neoplastic diseases, and methods of treatment of the diseases. Novel substituted N- (3-benzoylaminophenyl) -4-pyridyl-2-pyrimidinamine derivatives are excellent inhibitors of protein kinase activity, especially one or more Bcr-Abl, mutant Bcr- Ab1, c-Ab1, Raf, receptor tyrosine kinase PDGF-R, etc., as well as inhibition of two or more of these are shown. It can be used for the treatment of diseases associated with particularly abnormal or excessive activity of such types of kinases, such as leukemia, solid tumors. [Selection figure] None |