| abstract |
A human monoclonal antibody that binds to and inhibits human B lymphocyte surface antigen CD20 and a method for using the antibody are provided. A human anti-CD20 monoclonal antibody produced in a transfectoma or non-human transgenic animal capable of producing human antibodies of multiple isotypes by causing VDJ recombination and isotype switching. In addition, transgenic animals and hybridomas that produce the antibody, pharmaceutical compositions containing the antibody, and therapeutic and diagnostic methods using the antibody. [Selection figure] None |