| abstract |
The present invention provides a medically useful means by clarifying the expression of siglec 14 protein, the relationship between the similar siglec 5 protein and its function or gene level, and the like. The expression of Siglec 14 protein varies among individuals, and those who do not express Siglec 14 protein have a Siglec 14/5 fusion gene, and polymorphisms exist in the Siglec 14 gene. Siglec 14 protein is expressed on leukocytes, and this individual difference contributes to transfusion accidents. A cell that expresses Siglec 14 protein and a cell that does not express Siglec 14 protein have a significant difference in the amount of TNF-α produced and have different responses to infectious diseases. Therefore, detection of a polymorphism of the siglec 14 gene comprising a primer pair that specifically amplifies the siglec 14 gene, a probe that specifically hybridizes to the siglec 14 gene, or an antibody that specifically recognizes the siglec 14 protein. Reagents have been developed. [Selection figure] None |