| abstract |
In view of the deficiencies associated with prior art synthetic inhibitors, the present invention can potently inhibit 17α-hydroxylase / C 17,20 -lyase as well as 5α-reductase and block all androgen synthesis, It is an object to provide enzyme inhibitors that are beneficial in the treatment of prostate cancer and benign prostatic hypertrophy. The present invention relates to novel inhibitors of androgen synthesis useful in the treatment of prostate cancer and benign prostatic hypertrophy. The present invention also provides methods for synthesizing these novel compounds, pharmaceutical compositions containing these novel compounds, and methods for treating prostate cancer and benign prostatic hypertrophy using the androgen synthesis inhibitors of the present invention. I will provide a. [Selection figure] None |