| abstract |
Hydroxamic acid or carboxylic acid functional compounds (which can inhibit the production of tumor necrosis factor alpha (TNF-α)), pharmaceutical compositions containing such compounds, and therapeutic methods using such compounds To provide. The invention, in some embodiments thereof, comprises a novel class of MMP and TNF-α convertase inhibitors, pharmaceutical compositions containing one or more of the compounds, one or more Methods of preparing pharmaceutical formulations containing such compounds and methods of treating, preventing or ameliorating one or more symptoms of inflammation are provided. The compounds of the present invention can be administered in nasal form by using forms of transdermal skin patches well known to those skilled in the art, by topical use of a suitable nasal vehicle, or by transdermal route. To be administered in the form of a transdermal delivery system, the dosage administration will, of course, be continuous rather than intermittent throughout the dosage regimen. [Selection figure] None |