abstract |
The present invention provides a human monoclonal antibody that specifically binds to Fcα receptor (CD89), including a monoclonal antibody that specifically reacts with the Fc receptor of IgA of human effector cells. An isolated monoclonal antibody or antigen-binding fragment thereof comprising a specific heavy chain variable region sequence and a light chain variable region, which specifically binds to a human Fcα receptor (CD89). The antibody is a bifunctional antibody or heteroantibody and is useful for targeting a target cell (eg, cancer cell, infectious agent, etc.) to a target human effector cell (eg, macrophage). [Selection figure] None |