| abstract |
Viral infections such as hepatitis B (HBV), hepatitis C (HCV), and bovine viral diarrhea virus (BVDV) infections can be achieved by delivering pH-sensitive liposomes directly into the endoplasmic reticulum (ER) membrane. Can be treated. Two exemplary liposomal formulations are DOPE / CHEMS (DC liposome) and DOPE / CHEMS / PEG-PE (DCPP liposome). DC and DCPP liposomes can optimize the intracellular delivery of N-butyldeoxynojirimycin (NB-DNJ) and consequently increase the in vivo activity of this iminosugar by several orders of magnitude, yet interferon and / or ribavirin, etc. It could be used in combination with other therapeutic agents. Optimized release of NB-DNJ directly into the ER also applies to the treatment of other viruses such as human immunodeficiency virus (HIV), where NB-DNJ is known to be an effective antiviral agent be able to. |