| abstract |
The present invention relates to 3-substituted-1,5-diaryl-2-alkylpyrroles of formula I, pharmaceutical compositions containing them and their use for pharmacological treatment of pain and COX-2 overexpression related disorders About. The compound of the present invention is a novel pyrrole having a non-aliphatic side chain with several different functional groups at the 3-position of the pyrrole ring that confers related COX-2 potency and selectivity and significant oral efficacy to the compound Is a derivative. The phenyl ring is variously substituted at the 1- and 5-positions, but certain compounds of interest are substituted with a 4-methylsulfonylphenyl or 4-aminosulfonylphenyl group at the 5-position. I |