| abstract |
In the present invention, in order to improve the bioavailability in a drug, the amidine group in the drug is changed to N, N′-dihydroxyamidine (I) or N, N′-dihydroxyamidine ether (II) of [Chemical Formula 2]. N, N′-dihydroxyamidine diether (III), N, N′-dihydroxyamidine ester (IV), N, N′-dihydroxyamidine diester (V) or 4-hydroxy-1,2,4-oxadiazo The present invention relates to the manufacture of a drug which is phosphorus (VI). R in [Chemical Formula 2] represents a hydrogen atom, an alkyl group and / or an allyl group. |