| abstract |
The present invention relates to a method, a mixture, a kit and a composition relating to determination of an analyte by mass spectrometry using a labeling reagent. This labeling reagent contains a nucleophilic reactive group that reacts with the functional group of the analyte to form a labeled analyte. This labeling reagent may be a set of isobaric compound labels, a set of labels having different masses, or a set of combinations of isobaric compound labels and labels having different masses. Also, compounds with various general formulas (including sets that have the same general structural formula but include isotope-encoded compounds) are prepared in the form of both isobaric set and / or different mass sets can do. |