| abstract |
Since the biarylbenzimidazole derivative of the present invention has an excellent calcium inhibitory ability in HEK cells, it exhibits a strong antagonistic action on the vanilloid receptor and has an excellent analgesic effect. Acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, joint pain, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, neurological skin disease, stroke, bladder Irritability, irritable bowel syndrome, cough, asthma, chronic obstructive pulmonary disease, burns, psoriasis, pruritus (itching), vomiting, irritation of skin, eyes and mucous membranes, gastro-duodenal ulcer, inflammatory bowel disease, and It is useful for preventing or treating an effective disorder of antagonism of vanilloid receptor, which is one kind of disease selected from the group consisting of inflammatory diseases. |