| abstract |
The present invention relates to a nanodispersed antiparasitic agent, which provides a composition comprising at least one water-insoluble anti-parasitic agent and a water-soluble carrier material, said water-insoluble anti-parasitic agent (preferably artemisinin) Type drug or quinine type drug) is dispersed in the carrier material in nano-dispersed form with a peak diameter of nano-dispersed form of less than 1000 nm. The present invention further provides an aqueous dispersion of a water insoluble antiparasitic agent and a water soluble carrier material, wherein the antiparasitic agent is a nanodispersed form having a peak diameter of nanodispersed form of less than 1000 nm. The present invention further provides a method for preparing an antiparasitic composition comprising a water-insoluble antiparasitic agent and a water-soluble carrier, wherein a) the same anti-parasitic agent in a non-water-miscible solvent for the anti-parasitic agent And providing an emulsion comprising an aqueous solution of the carrier, or at least one non-aqueous solvent, optionally water, a water-soluble carrier material that is soluble in the mixture, and a water-insoluble that is soluble in the mixture Providing a mixture comprising an anti-parasitic agent, and b) drying the emulsion (preferably by spray drying) to obtain a nano-dispersion of a substantially solvent-free anti-parasitic agent in a carrier. And a method comprising any of the steps of removing water and a non-water miscible solvent. |