| abstract |
In many embodiments, the present invention provides novel compounds as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions comprising one or more such compounds. Disclosed are methods for the treatment, prevention, inhibition of one or more diseases associated with HDM2 protein or P53, using such compounds or pharmaceutical compositions. In one embodiment, the compounds of the invention have the general structure shown in Formula I herein: or a pharmaceutically acceptable salt, solvate, ester, or prodrug thereof. |