| abstract |
The present invention relates to the use of a PKC inhibitor for the manufacture of a medicament for the treatment or prevention of diabetic complications, wherein the PKC inhibitor is 3- (1.H.-indole-3- Yl) -4- [2- (4-Methyl-piperazin-1-yl) -quinazolin-4-yl] -pyrrole-2,5-dione, 3- (1.H.-indol-3-yl)- 4- [2- (Piperazin-1-yl) -quinazolin-4-yl] -pyrrole-2,5-dione, 3- [3- (4,7-diaza-spiro [2.5] oct-7- Yl) -isoquinolin-1-yl] -4- (7-methyl-1H-indol-3-yl) -pyrrole-2,5-dione or a pharmaceutically acceptable salt thereof. |