| abstract |
The present invention provides a composition comprising (i) a virus-like particle of an RNA bacteriophage, a virus-like particle, and (ii) an oligonucleotide packaged in the virus-like particle. Provide a method. Furthermore, the present invention provides a method for making a nucleotide composition comprising an oligonucleotide suitable for use in the above method. Furthermore, the present invention provides nucleotide compositions obtainable by the method of the present invention and uses thereof. Furthermore, the present invention comprises (i) a virus-like particle that is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide packaged in the virus-like particle, and the method of the present invention And provides a composition comprising a purity of preferably at least 98%, most preferably at least 99%. |