abstract |
The present invention relates to parathyroid-related disorders, such as HPT-JT, familial sporadic primary hyperparathyroidism (FIPH), and hyperparathyroidism-jaw tumor (HPT-JT) syndrome, Relates to the use of TGF-β antagonists for the treatment, amelioration and diagnosis of its associated complications. The present invention also relates to the use of a modulator of HRPT2 and its related PAF1 complex for the treatment, amelioration and diagnosis of TGFβ related disorders such as pulmonary hypertension, cancer, hypertension, fibrosis, wound healing. . Also provided are identification assays for modulators of HRPT2 / PAF1 and SMAD / TGFβ. |