| abstract |
Disclosed are combretastatin derivatives of general formula (I), methods for their production and uses. Here, R f is an alkyl group containing 1 to 8 carbon atoms and 1 to 17 fluorine atoms, R is an amino group, a substituted amino group, a hydroxy group, a nitro group, a halogen atom, an alkoxy group, a phosphate Or the side chain of an amino acid. The derivatives have the ability to suppress tubulin polymerization and are useful for the treatment of antitumor and antineoplastic blood vessels. [Chemical 1] [Selection figure] None |