abstract |
The present invention provides compounds, pharmaceutical compositions useful for modulating channel activating proteases, and prostasin, PRSS22, TMPRSS11 (eg, TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2) Use such compounds to treat, ameliorate, or prevent conditions associated with channel activating proteases, including but not limited to, matoptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, neutrophil elastase Provide a method. |