| abstract |
The present invention provides methods for modulating, eg, antagonizing, the activity of the hedgehog signaling pathway. In particular, the present invention relates to a loss of Ptc function, hedgehog function acquired type, smoothed function acquired type or Gli function acquired type comprising contacting a cell with a sufficient amount of a compound of the present invention (for example, a compound of formula I). A method of preventing an abnormal proliferative state caused by a phenotype such as |