| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-334
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-336
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-335
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-333
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3511
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-51 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 |
| filingDate |
2007-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2009-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2009535383-A |
| titleOfInvention |
Antisense agents combining oligonucleotides modified with strongly bound bases and artificial nucleases |
| abstract |
The present invention provides compounds having a chelating moiety and an oligonucleotide sequence, wherein the oligonucleotide comprises one or more modified nucleobases (eg, nucleobases substituted with hydroxy groups). The disclosed compounds are suitable for antisense therapy. The chelating moiety can form a complex with the lanthanide metal ion. These compounds are effective translation inhibitors of nucleic acids and have increased binding affinity for target nucleic acids. The present invention further includes compositions and methods of using these compositions as antisense therapy. |
| priorityDate |
2006-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |