| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14142
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-57 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74 |
| filingDate |
2007-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2009-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2009535339-A |
| titleOfInvention |
Modified AAV vectors with reduced capsid immunogenicity and uses thereof |
| abstract |
A method of reducing the cellular immune response and / or toxicity of AAV-mediated delivery is described. The method provides for inducing T cells and masking or eliminating the RxxR motif located on selected AAV capsids. The method further provides for reducing or eliminating heparin binding to AAV. Also provided are compositions containing the modified AAV capsids and methods of their use. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021137016-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11702676-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7132934-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019506445-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11124546-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020511127-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7309780-B2 |
| priorityDate |
2006-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |