| abstract |
Corresponding to the region of the human A33 gene promoter from base pair -105 to base pair +307, which can be used in conjunction with any other regulatory sequences, including sequences that respond to stress such as irradiation, hypoxia and free radical formation, and An isolated DNA sequence capable of controlling the expression of a heterologous gene. An assembly and viral vector for recombinant DNA expression is provided, which comprises the sequence of this human A33 gene promoter and at least one heterologous gene operably linked thereto. This regulatory sequence (s) controls the expression of at least one heterologous gene in cells, including colorectal cancer cells. Also described are pharmaceutical compositions and methods for treating colorectal cancer. |