http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009534460-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-47 |
| filingDate | 2007-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2009534460-A |
| titleOfInvention | Pyrimidine derivatives for the treatment of amyloid-related diseases |
| abstract | The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof; [Chemical 1] here X and Y are independently NR 5 or O; W and Z are independently a bond or (CH 2 ) m CH (R 7 ) (CH 2 ) n ; m is 0 to 1 and n is 0 to 2; R 1 and R 2 are independently hydrogen, halogen, CF 3 , OR 8 , OR 9 , NR 9 R 10 , NR 9 COR 11 , NR 9 SO 2 R 11 , SO 2 NR 9 R 10 , SO 2 R 11 or optionally and independently C 1-6 alkyl substituted with one or more of hydroxyl, C 1-6 alkoxy, halogen or NR 9 R 10 ; R 3 is hydrogen, halogen, CF 3 , OR 8 , COOR 9 , CONR 9 R 10 or SO 2 R 11 ; R 4 is hydrogen, halogen, CF 3 , OR 9 , NR 9 R 10 , NR 9 COR 11 , NR 9 SO 2 R 11 , SO 2 NR 9 R 10 , or hydroxyl, C 1-6 alkoxy or NR 9 R C 1-6 alkyl optionally substituted by 10 ; Or when R 3 and R 4 are in the ortho position and together form -O (CH 2 ) n O-, n is 1 to 3; R 5 is hydrogen or hydroxyl, C 1-6 alkoxy or C 1-6 alkyl optionally substituted with NR 9 R 10 ; R 6 is hydrogen, C 1-6 alkyl, C 1-6 alkoxy or NR 9 R 10 ; R 7 is hydrogen, C 1-6 alkyl, phenyl or C 1-3 alkylphenyl, wherein the phenyl group is selected from halogen, C 1-6 alkyl, CF 3 , OCF 3 or OR 9 A group optionally substituted with the above substituents; R 8 is hydrogen or C 1-6 alkyl optionally substituted with OR 9 or NR 9 R 10 ; R 9 is hydrogen, C 1-6 alkyl or C 1-3 alkylphenyl, and the phenyl group is selected from halogen, C 1-6 alkyl, CF 3 , OR 8 , NR 9 R 10 or OCF 3 A group optionally substituted by one or more substituents; R 10 is hydrogen, C 1-6 alkyl, C 1-6 alkenyl, phenyl or C 1-3 alkylphenyl, wherein the phenyl group is from halogen, C 1-6 alkyl, CF 3 , OR 8 or OCF 3 A group optionally substituted with one or more selected substituents; Or, the R 9 and R 10 groups together form a 5- or 6-membered ring optionally containing one of the additional heteroatoms selected from NR 9 , S and O when they are attached to a nitrogen atom. And; and R 11 is an alkyl or phenyl group optionally substituted with one or more substituents selected from halogen, C 1-6 alkyl, CF 3 , OCF 3 or OR 8 C 1-6 . These compounds are useful in the prevention and treatment of neurodegenerative diseases such as Alzheimer, Parkinson's disease and Huntington's disease and type II diabetes. [Selection figure] None |
| priorityDate | 2006-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 656.