| abstract |
[Chemical 1] The present invention relates to substituted pyrazinone derivatives according to general formula (I) having selective α 2C -adrenergic receptor antagonist activity, pharmaceutically acceptable acid or base addition salts thereof, stereochemical isomers thereof, N Regarding the oxide form or its quaternary ammonium salt, the variables are defined in claim 1. The invention further relates to their manufacture, compositions comprising them and their use as medicaments. The compounds according to the invention can be used for central nervous system disorders, mood disorders, anxiety disorders, stress-related disorders with depression and / or anxiety, cognitive disorders, personality disorders, schizophrenic disorders, Parkinson's disease, Alzheimer type dementia, chronic Useful for the prevention and / or treatment of painful conditions, neurodegenerative diseases, addiction disorders, mood disorders and sexual dysfunction. |