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filingDate 2007-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2009-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2009532410-A
titleOfInvention Process for the preparation of enantiomerically enriched cyclic β-aryl or heteroaryl carboxylic acids
abstract The present invention includes the following schemes (formulas I and II) wherein X is —C (R) (R ′) —, —N (R ″) —, —O—, —S (O) o —, C (O) N (R ″), —N (R ″) C (O) — or —C (O) —; R and R ′ are independently of each other hydrogen, C 1-7 -alkyl. , C 1-7 -alkyl (substituted with halogen, C 1-7 -alkoxy, hydroxy or — (CH 2 ) p —Ar); R ″ is hydrogen, C 1-7 -alkyl, halogen C 1-7 -alkyl, —S (O) o —C 1-7 -alkyl, —S (O) o —Ar, —S (O) o —NRR ′, — (CH 2 ) substituted with p- Ar, -C (O) -C1-7 -alkyl, -C (O) -Ar, -C (O) -NRR 'or -C (O) O- C1-7 -alkyl; Ar is Ally 1 or heteroaryl 1; n is an 0, 1, 2 or 3; m is an 0, 1, 2 or 3; o is 0, 1 or 2; p is 0, Is highly diastereoselective and highly enantioselective cis-substituted cyclic β-aryl or heteroaryl carboxylic acid derivatives by enantioselective hydrogenation and the corresponding salts thereof.
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Total number of triples: 48.