| abstract |
The present invention relates to substituted phenylpiperidine derivatives as melanocortin-4 receptor modulators. Depending on structure and stereochemistry, the compounds of the invention are either human melanocortin-4 receptor (MC-4R) selective agonists or selective antagonists. Agonists can be used to treat disorders and diseases such as obesity, diabetes and sexual dysfunction, while antagonists treat disorders and diseases such as cancer cachexia, muscle atrophy, anorexia, anxiety and depression. Useful for. In general, the compounds of the invention can treat all diseases and disorders that involve modulation of MC-4R. |