http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009531386-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4162 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 |
| filingDate | 2007-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2009531386-A |
| titleOfInvention | Use of kinase inhibitors for the treatment of certain resistant tumors |
| abstract | The present invention provides low molecular weight compounds that exhibit high affinity for the ATP pocket of ABL tyrosine kinase, ie tetrahydropyrrolo [3,4-c] pyrazoles. For example, these compounds are ATP-competitive tyrosine kinase inhibitors that also exhibit significant inhibitory potency, particularly against BCR-ABL inhibitor resistant T315I ABL mutants. The compounds of the present invention are useful in the treatment of BCR-ABL inhibitor resistant ABL mediated diseases such as imatinib resistant chronic myeloid leukemia. Furthermore, the present invention provides screening methods for the identification of compounds that can bind to the ATP pocket of kinase proteins, particularly T315I mutant ABL kinase. |
| priorityDate | 2006-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 163.