http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009531369-A
Outgoing Links
Predicate | Object |
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
filingDate | 2007-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2009-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-2009531369-A |
titleOfInvention | Malonamide derivatives as γ-secretase inhibitors |
abstract | The present invention relates to a malonamide derivative of the general formula (I) for treating Alzheimer's disease wherein A 1 is —CHR— or —C (O) —; A 2 is —C (O) — And R 2 / R 3 are independently of each other hydrogen, lower alkyl, halogen, hydroxy, lower alkoxy; A 2 is —OC (O) —, and R 2 / R 3 is Independently of one another, hydrogen or lower alkyl; R is hydrogen or lower alkyl substituted with halogen; R 1 is either hydrogen, lower alkyl or — (CH 2 ) n -aryl; And optionally substituted with halogen; R 4 is lower alkyl substituted with halogen; n is 0, 1, or 2) and its pharmacologically relevant It relates to acid addition salts, their optically pure enantiomers, their racemates and their diastereomeric mixtures. |
priorityDate | 2006-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 277.