http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009530600-A

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filingDate 2007-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2009-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2009530600-A
titleOfInvention A method for measuring molecular interactions by measuring light reflected by a flat surface.
abstract A method for determining the binding constant of the interaction of a ligand with a receptor comprising: a flat surface of a transparent solid material comprising a hydrophobic amorphous polymer and having a refractive index of 1.32 to 1.35; Or contacting the solution containing the reagent; adding a series of known volumes of the aqueous ligand solution to the solution; and measuring the light intensity value reflected from the interface between the solid material and the aqueous solution for each additional time A method comprising: fitting the measured value as a function of ligand addition in a Fresnel equation to obtain attached mass and fitting in a Langmuir equation to obtain a ligand-receptor affinity constant at equilibrium.
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Total number of triples: 20.