http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009530310-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6848 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-203 |
| filingDate | 2007-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2009530310-A |
| titleOfInvention | Substrate and internal standard for mass spectrometry detection |
| abstract | Provided is a substrate of the invention comprising a substrate compound represented by the formula: A- (B 1 -B 2 -B 3 ), wherein A is a sugar moiety, B 1 is the moiety A, and A linker moiety that allows conjugation to the rest of the substrate structure, and B 2 is permanently charged, such as a quaternary ammonium group, for increased proton affinity and ionization efficiency for analysis by mass spectrometry. B 3 has various carbon chain lengths that give specificity to the target enzyme. The present invention also provides a method for detecting lysosomal storage diseases by contacting a sample of the present invention with a sample together with an internal standard, wherein the internal standard is isotopically-labeled. It is an analog of a product obtained by cleavage when a target enzyme is allowed to act on the substrate. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2570562-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013511726-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-112017002818-T5 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018003652-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11061035-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019510204-A |
| priorityDate | 2006-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 164.