| abstract |
The present invention provides nitroxyl (HNO) under physiological conditions to treat and / or prevent the onset and / or progression of diseases or abnormalities in response to nitroxyl therapy, including heart failure and ischemia / reperfusion injury N-hydroxysulfonamide derivatives useful for Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by changing the type and position of functional groups on the N-hydroxysulfonamide derivative Is done. |