| abstract |
The present invention relates to a compound of formula (I): [Chemical 1] Or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , A and B are each described herein. Or a pharmaceutically acceptable salt), as well as, but not limited to, a gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD) ), Laryngopharyngeal reflux disease, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcer, gastritis, Helicobacter pylori infection, digestive disorder, functional digestive disorder, Zollinger-Ellison syndrome, non-erosive reflux (NERD), It relates to methods of treatment and use comprising said compounds for the treatment of conditions mediated by acid pump antagonist activity, such as visceral pain, cancer, heartburn, nausea, esophagitis, dysphagia, fluency, airway disorders or asthma. |