| abstract |
A compound represented by formula (I) or an optically active isomer thereof, which is used for the prevention and / or treatment of a disease caused by abnormal progression of tau protein kinase 1 such as a neurodegenerative disease (eg Alzheimer's disease), or Their pharmaceutically acceptable salts: Wherein, R 2 represents a hydrogen atom or the like; R 3 represents a methyl group or the like; R 20 represents a halogen atom; q is an integer of 0 to 3; Z represents a nitrogen atom or the like; R 4 Represents a hydrogen atom or the like; R 5 represents a hydrogen atom or the like; R 6 represents a substituted alkyloxy or the like; p represents an integer of 0 to 3; X represents a bond, CH 2 , an oxygen atom, NH or the like. Any combination of R 5 and R 6 , R 5 and R 4 , R 6 and R 4 , X and R 5 , X and R 4 , X and R 6 , and R 6 and R 6 are bonded to each other; May form a ring. |