abstract |
The present invention is a method for diagnosing a condition requiring or including regulation of cell death, differentiation, invasion, and / or cell fusion and turnover of trophoblast cells in a subject comprising HIF-1α As well as factors that regulate or are regulated by this protein, in particular TGFβ3, sFLT, VEGF, SMAD2, 3 and 7, MtdP, MtdL, McIl1, Mcllc, VHL, Siah1, Siah2, ENG, and PHD A method comprising the step of detecting is provided. The present invention relates to certain conditions that require or involve regulation of trophoblast cell death, differentiation, invasion, and / or cell fusion and turnover in a subject, particularly premature severe preeclampsia ( Further provided are methods for diagnosing or identifying EPE), late preeclampsia (LPE), and intrauterine growth retardation (IUGR). |