| abstract |
Methods and compositions for treating and preventing respiratory disorders are provided. The method of the present invention comprises a pharmaceutically acceptable salt of an A 1 adenosine receptor antagonist, in particular 1-hydroxy-2-naphthoate, or 3-hydroxy-2-naphthoate, more particularly , 3- [2- (4-aminophenyl) ethyl] -8-benzyl-7- {2- [ethyl- (2-hydroxyethyl) amino] ethyl} -1-propyl-3,7-dihydropurine-2 , 6-dione, comprising administering to the subject a therapeutically effective amount of 1-hydroxy-2-naphthoate (ie, L-97-1 xinafoate). Further provided are hydrates of A 1 adenosine receptor antagonist salts as described herein. The invention further encompasses a pharmaceutical composition comprising a pharmaceutically acceptable salt of an A 1 adenosine receptor antagonist in a pharmaceutically acceptable carrier. The compositions of the present invention find their use in the treatment and prevention of respiratory disorders. |