| abstract |
The present invention relates to methods for producing cancerous disease modifying antibodies using a novel screening paradigm. This method allows the production of anti-cancer antibodies for therapy and diagnosis by isolating anti-cancer antibodies using cancer cell cytotoxicity as an endpoint. These antibodies can be used to aid in cancer staging and diagnosis, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibody can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter components, and hematopoietic cells. [Selection] Figure 4 |