| abstract |
The present invention is directed to cinnoline and quinazoline compounds of formula (I) that are PDE10 inhibitors, pharmaceutical compounds containing them, and methods of preparing the compounds. The present invention is also directed to methods of treating diseases mediated by the PDE10 enzyme, such as obesity, non-insulin dependent diabetes mellitus, schizophrenia, or bipolar disorder, obsessive compulsive disorder and the like. [Chemical 1] [Selection figure] None |